Octopus: clinical trial update

Octopus logo

March 2025: Stage two of the Octopus Trial is open for recruitment at the Anne Rowling Clinic.

We are delighted to announce that we are now recruiting for stage 2 of the Octopus Multi-Arm Multi-Stage Clinical Trial.

Octopus is a UK-wide trial led by University College London. Octopus is testing whether particular drugs slow down disease progression for people who have progressive types of MS. Currently the potential treatments being tested are Metformin and Alpha-Lipoic Acid.

The Anne Rowling Clinic has already successfully recruited 48 participants to Octopus. These people will remain in the trial, and there will be no change for them.

Stage 2

New participants joining the trial will go into “Stage 2”. The only difference between Stage 2 and Stage 1 is that people participating in Stage 2 will not need to undergo MRI scans.

All data collected in Stage 2 will help the research team understand the safety of the treatments tested in Octopus and the potential benefit they could have on MS symptoms and disability.

We are very grateful to everyone who has participated in Octopus, without whom research like this wouldn't be possible. 

Funders and sponsors

Octopus is funded by the MS Society. The trial is sponsored by University College London

Related links

Octopus clinical trial page on the Anne Rowling Clinic website

Register interest in taking part in Octopus: MS-Register Octopus website (external website)

Octopus clinical trial webpages on MS Society website (external website)

Analysis stage 2 Frequently Asked Questions (external website)

Octopus trial reaches recruitment milestone (news article on MS Society website)

This article was published on: Monday, 31 March, 2025
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